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Why I Do This Work– A Mother’s Day Reflection with Valerie Thomas, Preeclampsia Survivor, Comanche Biopharma Co-Founder and Head of Patient Advocacy

Years ago, after a long and emotional journey with infertility, I became pregnant with twin daughters through IVF. Like many moms-to-be, I expected joy and excitement to define the experience. Instead, my third trimester was marked by worsening swelling, abnormal labs, and a sense that something just wasn’t right. I was eventually diagnosed with preeclampsia and admitted to the hospital at 33 weeks when doctors grew concerned that I was developing HELLP syndrome, a severe and potentially fatal complication of pregnancy.

My daughters were delivered six weeks early, and my condition progressed quickly. I was moved to the Obstetric ICU when my kidneys began to fail and my lungs filled with fluid. My daughters spent two weeks in the NICU. I spent a week in the hospital trying to stabilize.

Ten weeks post-partum, I began to hemorrhage due to retained placenta, an emergency I initially ignored because my physician had told me the bleeding I was experiencing was “normal”. By the time I was rushed into surgery, I had been bleeding for hours. As the team attempted to remove the tissue, the hemorrhage intensified. I lost four liters of blood during the procedure alone. I remained conscious as the room filled with people, equipment, and urgent voices. The team began transfusing me as I continued to hemorrhage, trying to keep pace with the blood loss. It was one of the most terrifying and surreal moments of my life.

I survived. My babies survived. But like too many women, I came far too close to becoming a statistic.

Today, my work at Comanche Biopharma comes from a place of purpose and experience. We are developing a therapy that targets a root cause of preeclampsia, the condition that nearly cost me my life. In the aftermath, I felt an overwhelming sense of guilt that my body had failed me and heartbreak in accepting that it was too dangerous for me to ever be pregnant again. I know the fear, the trauma, and the way those memories stay with you. That experience is never far from my mind. It drives my determination to help bring meaningful progress to maternal health, because far too many women are still facing these risks with far too few answers.

This Mother’s Day, I am filled with gratitude. I have had the joy of raising two incredible daughters, Madeline and Molly, who are now chasing their dreams in graduate school and a career in the healthcare sector. The chance to be their mom has been life’s greatest gift. I am proud to do this work with the hope that more women, everywhere, will be able to experience safe, healthy pregnancies and the profound joy that motherhood can bring.

Meet Our Patient Advisory Board

You are not alone and not to blame.

Preeclampsia is not your fault. It is a complex disease that does not discriminate and affects many pregnant women around the world.

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Comanche is a biopharmaceutical company developing an investigational siRNA medicine for preterm preeclampsia. We envision a world where all women and their babies have access to safe and effective therapies for treating life threatening complications of pregnancy, and those solutions must be evidence-based and affordable.

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