Comanche Biopharma was founded by an experienced group of physicians, researchers, biologists, chemists, ethicists, and pharmaceutical professionals determined to tackle the problem of preeclampsia.
We recognize the challenge of drug development for mothers and babies and are committed to the women and their families who have been disproportionately underserved by the drug industry for decades.
Comanche believes every mother has the right to choose evidence-based therapies that have been appropriately studied to determine their risk:benefit and solve life-threatening conditions of pregnancy.
Our Inspiration
The company is named in honor and appreciation of the innovations achieved by the Numunuu people which allowed them to become a global power on the North American continent for over two hundred years.
In particular, these American Indians controlled an empire encompassing much of the Southwestern United States and northern Mexico (referred to as Comancheria, hence the name Comanche).
Their adoption of the horse as a disruptive technology along with innovations in animal husbandry, training and utilization reshaped worldwide politics, economics, markets, and cultures.
We are inspired by this example of purposeful innovation and recognize that new technologies alone are not enough to affect meaningful change.
Our Company Values
Quality
Demonstrating that we care greatly throughout all we do
Trust
Continually building competency, consistency, transparency, mutuality
Beneficence
Duty to help others
Non-malfeasance
Intent to do no harm
Scientific method
A process for ensuring the integrity of our work
Kindness
Respect for others by listening and acting with empathy
Leadership
‘How’ is as important as ‘what’ and more important than ‘who’
Fair and equal access globally
Delivering therapies that create measurable value for society, are cost-effective, and accessible
Meaning of the 3 Layers

Our goal is to design development and commercialization processes that create affordable solutions that solve real needs and in the process deliver meaningful value to society that is measurable.
Comanche Biopharma is committed to the ethical representation of all people of color and economic status in our clinical development programs.
We prioritize ensuring access to our solutions by those who need them most.
Our Team

Scott holds a B.S. in chemistry (Phi Beta Kappa) and an M.D. (Alpha Omega Alpha) from the University of Alabama. His academic career included faculty positions at Harvard Medical School, the University of Colorado Medical School, and the University of South Alabama. He has been Board Certified in Internal Medicine, Pulmonary and Critical Care Medicine and Sleep Disorders Medicine. He currently is a Board member at Atalanta Therapeutics, a biopharmaceutical company focused on the application of RNA interference to diseases of neurodegeneration.


Previous to Comanche, Allison was Vice President of Clinical Development, Infectious Diseases at Moderna and spent over five years in various roles with increasing responsibility for the development of mRNA-based vaccines and the first mRNA-encoded monoclonal antibody. Allison has led multidisciplinary teams on the successful execution of clinical programs from Phase 1 through Phase 3, including serving as the clinical lead for the Phase 3 pivotal efficacy trial for the COVID-19 mRNA vaccine.
During her tenure at Moderna, she was the clinical lead responsible for advancing several vaccines including RSV, hMPV-PIV, Zika and Chikungunya and led the Medical Affairs team for CMV and other latent virus vaccines. Prior to Moderna, Allison headed the global clinical team for the RSV maternal immunization vaccine program at Novavax. Prior to Novavax, Allison worked in translational medicine, early and exploratory clinical development, and Phase 1 through Phase 3 vaccine trials, including maternal immunization, for Novartis Vaccines and Diagnostics.
Before moving to the biopharma industry, Allison was an academic and private practice obstetrician-gynecologist. Her academic career included faculty positions at the Brown University Medical School and adjunctive faculty at the Harvard Medical School affiliated hospitals. Allison holds a B.A. in the History of Religion from Bryn Mawr College and an M.D. from the University of Chicago, Pritzker School of Medicine. She was Board Certified in Obstetrics and Gynecology after completing her residency training at Brown University.

Previously, Mr. Antinori was Senior Vice President, General Counsel and Secretary of The Medicines Company, a publicly traded pharmaceutical company. During his tenure, the company grew from $15 million in revenue generated from one product in one country to over $700 million from multiple products sold globally.
Prior to The Medicines Company, Mr. Antinori was General Counsel at Physician Computer Network, Inc., a publicly traded healthcare information technology company. Prior to his in-house positions, Mr. Antinori was a partner at the Gibbons law firm in Newark, NJ and, before Gibbons, at other major law firms in New York and New Jersey.
Mr. Antinori received his J.D. from the University of Virginia School of Law and his B.A. from Boston College (Summa Cum Laude; Phi Beta Kappa).



Michael has worked as a designer at startups and at a large consulting firm, using his designs and innovation to help companies secure multimillion-dollar contracts and connect with their audiences.
Michael also has a background in IT, marketing, and sales, all of which inform his designs and awareness of user interface and experience. He attended Art Center College of Design in Pasadena, California.

Mandy's fundamental belief is that a robust Quality Culture begins and ends with the People and an uncompromising focus on patient health. An effective Quality program must be founded upon a combination of applicable technical expertise, a passion for innovation & compassion for the patients in need. Mandy holds a MS Degree in Leadership from Northeastern University, a Bachelor's degree in Biology from UMASS and Post Grad professional certifications Six Sigma Lean, Risk Management & Data Analytics from Stanford University & MIT.



Max has a BA in Government & Law from Lafayette College.

Dr. Motheram has 27 years of diversified professional experience in pharmaceutical R&D in various aspects of pharmaceutical development ranging from development of early phase clinical products to commercial dosage forms, scale-up and technology transfer. Dr. Motheram has extensive CMC expertise in both small and large molecules leading to the development of several commercial products in a range of therapeutic areas including HIV, Oncology, Cardiovascular, Anti-infective and Critical Care medicine.
Dr. Motheram’s Ph.D. dissertation work involved characterizing the adsorption of proteins at solid/liquid interfaces and the structural changes of adsorbed proteins. His research interests include design, development, and optimization of oral and parenteral dosage formulations, and designing novel drug delivery systems for small molecules as well as biologics. Dr. Motheram is a co-inventor on patents concerning novel pharmaceutical compositions and co-authored manuscripts published in peer reviewed journals.




Our Scientific Advisory Board




Prior to UMass Chan Medical School, Dr. Khvorova spent 12 years in industry in different executive positions. She has co-founded several biotechnology companies.
Dr. Khvorova is named as inventor on more than 150 patents and 300 patent applications and has authored more than 100 peer-reviewed publications, including seminal articles in Cell, Nature, and Nature Biotechnology, defining the field of RNAi drug design and development. She has served as a director of the Oligonucleotide Therapeutics Society and currently is Director-at-Large and Scientific & Research Council Chair of the American Society of Gene and Cell Therapy.

In his role as Chief Academic Officer, Dr. Thadhani oversees a ~$1.8B research enterprise, graduate medical education, and continuing professional development for Mass General Brigham. Dr. Thadhani is a member of the Mass General Brigham executive leadership team under the direction of Anne Klibanski, M.D., President and Chief Executive Officer. Dr. Thadhani works with senior leadership across the Mass General Brigham system on a number of system strategic initiatives.
Dr. Thadhani also managed a successful research laboratory for approximately 25 years with continuous federal funding and employing data managers, operations directors, statisticians, nurses, research assistants, and laboratorians. He has published more than 300 manuscripts, including in the top Medical and Nephrology journals – New England Journal of Medicine, Journal of the American Medical Association, and Journal of the American Society of Nephrology. Dr. Thadhani has been inducted to several honor societies, including the American Society for Clinical Investigation, Association of American Physicians, American Epidemiological Society, and the American Clinical and Climatological Association. He has also received several distinguished national awards, including the Harold Amos Faculty Diversity Award from Harvard Medical School – the highest award for Fostering Diversity at Harvard Medical School; Alumni Award from the Harvard School of Public Health – a significant achievement, and the John P. Peters Award from the American Society of Nephrology – for Mentorship and Scientific Achievements.
Our Patient Advisory Board

Utilizing the reach of the internet and social media to provide support and information, one of EndPreeclampsia’s programs, Preeclampsia, Eclampsia & HELLP Syndrome Survivors Global Support Network, has grown to over 37,000 members in 115 countries. This volunteer-run, evidence-based online community gains 1,000 new members per month seeking support and information about pregnancy health. Another program, Butterfly Brigade, is a group of women with lived maternal health complication experience who visit hospitalized antepartum mothers experiencing complications and extended hospital stays to deliver support and essential personal care supplies.
Kara is also a Patient Advisor for several organizations and research studies, including the Illinois Perinatal Quality Collaborative, the Iowa Maternal Quality Care Collaborative, and a member of several other state PQC’s. She runs an independent forum for patient advocates of PQCs to streamline communication, share ideas, and engage people in advocacy and advisory work. She is the Patient Advisor for the $10 Million HRSA Grant partnership between the University of Iowa Health Care and the Iowa Department of Public Health to improve maternal outcomes and a Stakeholder Advisory Board member of the Institute of Clinical and Translational Science at the University of Iowa.
Kara was the HOPE Award Recipient for Maternal Health Volunteer of the Year in 2009 and the Champions for Change Maternal Health Champion of the Year award recipient in 2019. She has led charitable giving initiatives raising hundreds of thousands of dollars for Maternal Health causes.



With over 10 years of childcare and birthwork experience, Nicole brings a wealth of knowledge and believes all families should have access to evidence-based information and resources about birth and parenthood. She is a valuable resource and is committed to collaborating with community members and practitioners to compile much-needed resources for families. Nicole wants families to feel excited and empowered about this life-changing event. Having a village is essential to positive maternal and infant mortality rates, and parents should have access to the providers, services, and support groups that will help them along their journey. Nicole is a member of Chicago Birthworks Collective, Breastfeed Chicago board member and Wisconsin Association of Lactation Consultants board member. She is currently the Birth Outcomes Made Better (BOMB) Doula Program Manager at the City of Milwaukee Health Department.

Dr. Moore’s research at UMMS and HHMI encompassed a broad array of topics related to the role of RNA and RNA-protein (RNP) complexes in gene expression. She is particularly known for her mechanistic and structural analyses of spliceosomes and mRNPs, co-discovery of the exon junction complex (EJC), and studies of intracellular RNA transport and quality control pathways. She was also instrumental in developing multiple enabling technologies for the field, including methods for introducing site-specific modifications into long RNA molecules and single molecule methods for observing the dynamics of RNP complex assembly and disassembly. At Moderna Therapeutics, Moore directs research into novel delivery mechanisms for therapeutic mRNAs and how to increase their functional and longevity.

I am a two-time survivor of HELLP/Preeclampsia. My daughter, Sabrina, was delivered via emergency c-section at 27 weeks due to HELLP Syndrome. Thankfully my second pregnancy lasted 34 weeks until symptoms were presented and my son, Dante, was delivered healthy.

Nasia is not only a successful professional but also a dedicated mother, raising a beautiful family of six alongside her fiancé. Together, they have four energetic boys and a playful soon-to-be one-year-old mini/ doodle dog, all of whom she adores deeply.
Having faced the challenges of preeclampsia during three pregnancies, Nasia knows firsthand the immense impact this condition can have on a family. She is now committed to sharing her heartfelt story with others, both to educate and to help individuals plan a life that fights against the odds of being diagnosed with
preeclampsia.
As a member of the patient advisory board, Nasia brings valuable insights from her personal experiences, as well as her exceptional skills in organization and communication. Her passion for connecting people and her determination to make a difference will undoubtedly contribute to Comanche’s mission of raising awareness and improving outcomes for those affected by preeclampsia.

Valerie lives in Indianapolis with her husband of 27 years, and they have twin daughters who are in their sophomore year at the University of Alabama. She began to show signs of preeclampsia at 28 weeks pregnant and was admitted to the hospital at 33 weeks when she developed HELLP syndrome. Madeline and Molly were born at 34 weeks and spent two weeks in the NICU, while Valerie spent one week in the hospital recovering. She is determined to create a future free of this disease.

Prior to joining Silicon Valley Bank, Megan was a Blavatnik Fellow at Yale University. She worked at the intersection of venture creation and development of life science start-ups at various stages within the Yale ecosystem.
Prior to becoming a Blavatnik Fellow, Megan worked at Mayo Clinic Ventures. During her two years with the MCV team, she collaborated with business development colleagues to bridge the technology development and funding gap between academia and industry.
Megan earned a Ph.D. in Molecular Medicine at Hofstra School of Medicine in a translational research lab, and she studied the regulation of autoimmune B Cells in lupus nephritis. In addition to her Ph.D., Megan holds a B.S. in Biology at Prairie View A&M University.
Our Board of Directors


In 2020, Felix broke records after winning her bronze and gold medal at the Tokyo Olympics - her fifth and final Olympic games. She continued to make history during the games, by sporting racing spikes created by her company – lifestyle and footwear brand, Saysh – becoming the first Track & Field athlete to do so. Publicly launched post Games in June 2021, Saysh not only aims to create an encouraging and supportive community for women, but it also designs and manufactures athletic-inspired footwear made for and by women, unlike most brands, whose shoes are created based off of men’s feet and footwear. Running in her own spikes on the largest stage in the world, Felix exemplified that she is about more than just medals – she was running for change, equity and acceptance for women and girls everywhere. In keeping with its mission to empower and serve women, Saysh sought out women-led, women-funded partners for the brand’s recent Series A fundraising round, which brought in $8 million and included the Gap Inc.-owned Athleta brand. Current products include the Saysh One, the Saysh Two and the Scarf by Saysh.
Off the track, Felix is a fierce advocate for maternity rights for all women. In 2019, she wrote an opinion piece for The New York Times that called out Nike, her former sponsor, for not providing guaranteed protections for pregnant athletes and new moms. (Felix gave birth to her daughter Camryn in 2018.) The public reaction to the piece put pregnancy discrimination in athletics in the spotlight, and the practice was heavily criticized. More female athletes came to Felix’s side, offering up their stories. During the 2020 Olympics, Felix alongside her new sponsor Athleta, created the Power of She Fund: Child Care Grant – a fund to assist mom-athletes with childcare while competing at the games.

Ann received her M.D. from Harvard Medical School, after receiving her B.A. in Biology magna cum laude from the University of California, San Diego. She completed her internship and residency in Internal Medicine, and her fellowship in Endocrinology and Metabolism at Massachusetts General Hospital, before joining the faculty there.
She is passionate about bringing the patient voice to everything she does and has a particular interest in health equity and women’s health.
In addition to Comanche, she serves on the Boards of Terns Pharmaceuticals and UnLearn AI, as well as two non-profits, the New England Advisory Board of the Trust for Public Land and the Yleana Leadership foundation, which is improving the racial wealth gap by getting underserved kids into better colleges, with better financial aid packages, higher graduation rates, and better paying jobs. She also serves as Co-Chair of the National Academies of Science, Engineering and Medicine Forum on Drug Discovery, Development, and Translation.

Dr. Patel focuses on investing in therapeutics and medical device companies and has served on the Board of Directors of ABK Biomedical, Aclaris Therapeutics (NASDAQ:ACRS), Avalyn Pharma, Caplin Steriles, Comanche Biopharma, Eywa Pharma, Ivenix (acquired by Fresenius Kabi), Laurus Labs (NSE:LAURUSLABS), Medwell Ventures, Menlo Therapeutics (NASDAQ:MNLO), NextWave Pharmaceuticals (acquired by Pfizer), NFlection Therapeutics, Pediatrix Therapeutics, Rallybio (NASDAQ:RLYB), and Vicept Therapeutics (acquired by Allergan).
Dr. Patel is a graduate of Tufts University School of Medicine, where he received both his MD and MBA as part of that institution’s Healthcare Management Program and was elected to the Alpha Omega Alpha Medical Honor Society. He completed his undergraduate studies in biology and economics with highest honors at Rutgers University.

Before GV, Brendan’s career focused on applied statistics and machine learning research in genetics and biotechnology. He designed machine learning models for personalized immuno-oncology therapeutics at Gritstone Oncology and developed methods for statistical genetics research at the Broad Institute. Brendan’s work has been published in journals including Nature, Science, Nature Biotechnology, and Nature Genetics. In his free time, Brendan enjoys reviewing data and reading scientific journals. Brendan is interested in innovative therapeutic biotechnology and diagnostics across all stages and therapeutic areas.
Brendan has a B.A. in mathematics from the University of California, Berkeley, and a Ph.D. in statistical genetics from Vrije Universiteit Amsterdam.

Clive was deeply involved in the development and commercialization of many biopharmaceutical products – including Neupogen®, a leading oncology product; Angiomax®, the top-selling anticoagulant for cardiac procedures in US hospitals; and Leqvio® for cholesterol lowering – throughout a career spanning four decades.
Clive is also Vice Chairman of BB Biotech, a listed investment corporation which invests in mainly public biotech firms, and a director of Fractyl Health, Comanche Biopharma, EQRx, and Hugo Health.
After a series of senior executive positions with Roche in Switzerland and the US in product development, regulatory affairs, and marketing, he founded, built, and led The Medicines Company, a biopharmaceutical company focused on acute hospital care, before pivoting the firm to the population health challenges of cardiovascular disease. The Medicines Company was sold to Novartis for $9.7 billion in January 2020.
Clive trained in medicine, with post-graduate specialization in cancer research, clinical trials, statistics, and epidemiology. He holds MB ChB and MD cum laude degrees from the University of Birmingham, UK.

Dr. Levin has also held senior drug development roles at miRagen Therapeutics, Santaris Pharma, and Ionis Pharmaceuticals (formerly Isis). He has four decades of experience in all aspects of drug development from discovery through drug registration, both in large pharma and biotech companies. Dr. Levin has published over 100 scientific articles and several of the most cited reviews in the field. He received a doctorate in toxicology from the University of Rochester, and a bachelor’s degree in biology from Muhlenberg College.

Scott holds a B.S. in chemistry (Phi Beta Kappa) and an M.D. (Alpha Omega Alpha) from the University of Alabama. His academic career included faculty positions at Harvard Medical School, the University of Colorado Medical School, and the University of South Alabama. He has been Board Certified in Internal Medicine, Pulmonary and Critical Care Medicine and Sleep Disorders Medicine. He currently is a Board member at Atalanta Therapeutics, a biopharmaceutical company focused on the application of RNA interference to diseases of neurodegeneration.
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Concord, MA 01742